A racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. An HMG-CoA reductase inhibitor, it is used (often as the corresponding sodium salt) to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia.
Synonyms: rac-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
Term information
- DrugBank:DB01095
- CAS:93957-54-1
- KEGG:D07983
- Patent:WO8402131
- PMID:12147804
- PMID:18413661
- PMID:23846727
- PMID:11273020
- KEGG:C07014
- Patent:US4739073
- PMID:18936176
- PMID:18410471
- PMID:18452779
- PMID:23212095
- Wikipedia:Fluvastatin
- Beilstein:9168031
3_STAR
PMID:18936176
DrugBank:DB01095
KEGG:D07983
CAS:93957-54-1
Beilstein:9168031
Wikipedia:Fluvastatin
PMID:12147804
Patent:WO8402131
PMID:18410471
PMID:18413661
PMID:23212095
PMID:11273020
Patent:US4739073
PMID:23846727
PMID:18452779
KEGG:C07014
rac-(3R,5S,6E)-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid
fluvastatinum
fluvastatina
(6E)-erythro7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
fluvastatin
Cranoc
(+-)-fluvastatin
rac-(3R,5S)-fluvastatin
erythro-(E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-(1''-methylethyl)indol-2'-yl]hept-6-enoic acid
fluvastatine
InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m0/s1