A member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke.
Synonyms: 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
Term information
- Drug_Central:2799
- PMID:20717044
- CAS:181695-72-7
- Wikipedia:Valdecoxib
- LINCS:LSM-5305
- PMID:21769548
- KEGG:D02709
- PMID:21073910
- PDBeChem:COX
- PMID:20467258
- HMDB:HMDB0005033
- Reaxys:8563786
- DrugBank:DB00580
- PMID:21720517
3_STAR
PMID:21073910
CAS:181695-72-7
PDBeChem:COX
PMID:20467258
Reaxys:8563786
KEGG:D02709
PMID:20717044
LINCS:LSM-5305
Wikipedia:Valdecoxib
PMID:21769548
HMDB:HMDB0005033
DrugBank:DB00580
Drug_Central:2799
PMID:21720517
valdecoxib
p-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
Bextra
valdecoxibum
InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)