An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
Synonyms: {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
Term information
- KEGG:D03714
- PMID:22142375
- Drug_Central:1618
- HMDB:HMDB0015403
- PMID:15456339
- PMID:17380211
- PDBeChem:LUR
- PMID:22069133
- Reaxys:9784107
- PMID:14965322
- Wikipedia:Lumiracoxib
- PMID:22732767
- PMID:22621454
- CAS:220991-20-8
- PMID:15311562
- DrugBank:DB01283
- PMID:19800190
- PMID:21688392
3_STAR
HMDB:HMDB0015403
Drug_Central:1618
PMID:22069133
PMID:22621454
PMID:22732767
PMID:15311562
PMID:21688392
Reaxys:9784107
PMID:14965322
PDBeChem:LUR
Wikipedia:Lumiracoxib
PMID:17380211
CAS:220991-20-8
PMID:15456339
PMID:19800190
KEGG:D03714
PMID:22142375
DrugBank:DB01283
COX189
Prexige
2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid
lumiracoxibum
COX 189
COX-189
lumiracoxib
InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20)