A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Synonyms: 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nimodipine
Term information
- KEGG:D00438
- Wikipedia:Nimodipine
- KEGG:C07267
- PMID:22300914
- CAS:66085-59-4
- PMID:8519001
- Reaxys:459792
- PMID:22262041
- Patent:US3799934
- LINCS:LSM-1659
- Drug_Central:1937
- PMID:17110283
- Patent:DE2117571
- PMID:12137606
- PMID:21869451
- PMID:16180362
- DrugBank:DB00393
3_STAR
PMID:8519001
Reaxys:459792
PMID:16180362
PMID:22300914
Wikipedia:Nimodipine
Drug_Central:1937
CAS:66085-59-4
PMID:22262041
PMID:17110283
Patent:DE2117571
Patent:US3799934
PMID:12137606
PMID:21869451
LINCS:LSM-1659
DrugBank:DB00393
KEGG:D00438
KEGG:C07267
BAY e 9736
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester
nimodipine
Periplum
nimodipino
nimodipinum
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
Nimotop
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3