A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
Synonyms: Rofecoxib 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
Term information
- DrugBank:DB00533
- Reaxys:8269007
- PMID:28166217
- KEGG:D00568
- PMID:10859630
- Drug_Central:2397
- PMID:12069696
- LINCS:LSM-2482
- PMID:16934051
- PMID:20162413
- KEGG:C07590
- Beilstein:8269007
- Wikipedia:Rofecoxib
- PMID:11014111
- CAS:162011-90-7
3_STAR
PMID:20162413
PMID:16934051
Beilstein:8269007
LINCS:LSM-2482
PMID:12069696
PMID:10859630
PMID:28166217
CAS:162011-90-7
Drug_Central:2397
KEGG:C07590
DrugBank:DB00533
Wikipedia:Rofecoxib
PMID:11014111
KEGG:D00568
Reaxys:8269007
rofecoxib
Vioxx
Ceoxx
3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
rofecoxibum
InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3