A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
Synonyms: Sulindac {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
Term information
- DrugBank:DB00605
- Wikipedia:Sulindac
- CAS:38194-50-2
- KEGG:D00120
- Patent:US3654349
- KEGG:C01531
- PMID:11569947
- Patent:DE2039426
- Drug_Central:2534
- Reaxys:2951842
- PMID:15020200
- PMID:12406542
- PMID:19884509
- PMID:23689354
- PDBeChem:SUZ
- PMID:11927004
- PMID:15123337
- Beilstein:2951842
- PMID:23804703
- HMDB:HMDB0014743
3_STAR
HMDB:HMDB0014743
PMID:19884509
Patent:US3654349
Wikipedia:Sulindac
KEGG:D00120
Reaxys:2951842
Patent:DE2039426
PMID:11569947
DrugBank:DB00605
PMID:15020200
CAS:38194-50-2
PMID:23689354
Beilstein:2951842
PMID:12406542
KEGG:C01531
PMID:11927004
PDBeChem:SUZ
PMID:23804703
Drug_Central:2534
PMID:15123337
(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
sulindac
cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
Sulindacum
Clinoril
sulindaco
cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-