A protein complex that plays a role in the intramembrane cleavage of integral proteins such as Notch receptors and amyloid beta A4 protein.
Synonyms: Gamma-Secretase Gamma Secretase
This is just here as a test because I lose it
Term information
DesignNote
The components required for the enzymatic activity of gamma secretase are a homodimer of presenilin (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. The proteolytic activity appears to be mediated by presenilin, while the other proteins are required for both stabilization of the active form of presenilin and localization of the complex.