A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. [ GOC:curators http://www.ncbi.nlm.nih.gov/pubmed/12537518 http://www.ncbi.nlm.nih.gov/pubmed/11728327 GOC:rn ]
Synonyms: DNA replication checkpoint signal transduction involved in DNA replication checkpoint