A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission). [ http://www.ncbi.nlm.nih.gov/pubmed/17556548 http://www.ncbi.nlm.nih.gov/pubmed/31132588 http://www.ncbi.nlm.nih.gov/pubmed/34449766 http://www.ncbi.nlm.nih.gov/pubmed/28242692 http://www.ncbi.nlm.nih.gov/pubmed/22361144 http://www.ncbi.nlm.nih.gov/pubmed/32243490 ]