A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [ GOC:txnOH-2018 http://www.ncbi.nlm.nih.gov/pubmed/10213677 http://www.ncbi.nlm.nih.gov/pubmed/16858867 ]

Synonyms: transcription co-repressor activity

This is just here as a test because I lose it

Term information

comment

For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.

creation date

2010-11-24T03:14:44Z

has alternative id

GO:0001106

has obo namespace

molecular_function

has related synonym

RNA polymerase II transcription corepressor activity

RNA polymerase II transcription co-repressor activity

id

GO:0003714

term tracker item

https://github.com/geneontology/go-ontology/issues/20464

https://github.com/geneontology/go-ontology/issues/28926

https://github.com/geneontology/go-ontology/issues/15998

https://github.com/geneontology/go-ontology/issues/15665