long-chain fatty acid-CoA ligase activity
Go to external page http://purl.obolibrary.org/obo/GO_0004467
Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [ https://www.rhea-db.org/rhea/15421 ]
Synonyms: long-chain-fatty-acyl-CoA synthetase activity long-chain-fatty-acid-CoA ligase activity long-chain acyl-CoA synthetase activity
Term information
- Reactome:R-HSA-193727 (TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS))
- EC:6.2.1.3
- Reactome:R-HSA-5696004 (ACSF2 ligates CoA-SH to MCFA)
- Reactome:R-HSA-2046098 (Activation of linoleic acid to linoleoyl-CoA)
- RHEA:15421
- Reactome:R-HSA-548843 (ACSL3,4 ligate CoA to AA to form AA-CoA)
- Reactome:R-HSA-9734535 (SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA)
- Reactome:R-HSA-193766 (TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS))
- MetaCyc:RXN-7904
- Reactome:R-HSA-193401 (THCA is conjugated with Coenzyme A (SLC27A2 VLCS))
- Reactome:R-HSA-159425 (Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS))
- Reactome:R-HSA-193743 (3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS))
- Reactome:R-HSA-192137 (THCA is conjugated with Coenzyme A (SLC27A5 BACS))
- Reactome:R-HSA-201035 (ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA)
- Reactome:R-HSA-193711 (3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS))
- Reactome:R-HSA-193424 (DHCA is conjugated with Coenzyme A (SLC27A2 VLCS))
- Reactome:R-HSA-2046085 (Activation of alpha-linolenic acid to alpha-linolenoyl-CoA)
- Reactome:R-HSA-193407 (DHCA is conjugated with Coenzyme A (SLC27A5 BACS))
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
LCFA synthetase activity
long-chain acyl CoA synthetase activity
long chain fatty acyl-CoA synthetase activity
long-chain acyl-coenzyme A synthetase activity
lignoceroyl-CoA synthase activity
thiokinase
acyl-CoA ligase activity
long-chain fatty acid activation
long-chain fatty acyl coenzyme A synthetase activity
fatty acid thiokinase (long-chain) activity
acyl-CoA synthetase activity
https://github.com/geneontology/go-ontology/issues/20462
https://github.com/geneontology/go-ontology/issues/28526
https://github.com/geneontology/go-ontology/issues/26445
https://github.com/geneontology/go-ontology/issues/25799
https://github.com/geneontology/go-ontology/issues/18967