Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [ https://enzyme.expasy.org/EC/3.1.3.48 ]
Term information
- Reactome:R-HSA-997311 (Dephosphorylation of TYK2 by PTP1B)
- Reactome:R-HSA-9603719 (Protein tyrosine phosphatases dephosphorylate NTRK3)
- Reactome:R-HSA-9698408 (PTPRJ dephosphorylates active FLT3)
- Reactome:R-HSA-8867047 (PTPN3 dephosphorylates EPS15)
- Reactome:R-HSA-391868 (Dephosphorylation of NCAM1 bound pFyn)
- RHEA:10684
- Reactome:R-HSA-9636439 (PtpA:Ub dephosphorylates p-Y133-VPS33B)
- Reactome:R-HSA-377643 (Dephosphorylation of inactive SRC by PTPB1)
- Reactome:R-HSA-8864125 (PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248)
- Reactome:R-HSA-9700200 (PTPRZ dephosphorylates ligand-bound ALK dimers)
- Reactome:R-HSA-9701507 (PTPN6 dephosphorylates JAK3)
- Reactome:R-HSA-914036 (SHP1 and SHP2 dephosphorylate Y628 of IL3RB)
- Reactome:R-HSA-8867658 (PTPN3 dephosphorylates MAPK12)
- Reactome:R-HSA-202214 (Dephosphorylation of Lck-pY505 by CD45)
- Reactome:R-HSA-445089 (Dephosphorylation of pL1 (Y1176))
- Reactome:R-HSA-9865167 (PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2))
- Reactome:R-HSA-1169210 (PTP1B dephosphorylates JAK2)
- Reactome:R-HSA-74747 (Dephosphorylation of p-Y-IRS1,p-Y-IRS2)
- Reactome:R-HSA-1169188 (SHP1 (PTPN6) dephosphorylates JAK2)
- EC:3.1.3.48
- Reactome:R-HSA-8863804 (PTPN12 dephosphorylates ERBB2 on tyrosine Y1248)
- Reactome:R-HSA-8864029 (PTPN12 dephosphorylates EGFR at Y1172 (Y1148))
- Reactome:R-HSA-5683967 (EYA1-4 dephosphorylates tyrosine Y142 of H2AFX)
- Reactome:R-HSA-1169192 (PTP1B dephosphorylates GHR)
- Reactome:R-HSA-997314 (Dephosphorylation of JAK1 by SHP1)
- Reactome:R-HSA-9674816 (p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS)
- Reactome:R-HSA-8937767 (PTPN11 dephosphorylates RUNX1)
- Reactome:R-HSA-9635461 (PtpA dephosphorylates GSK3A)
- Reactome:R-HSA-997326 (Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP)
- Reactome:R-HSA-8855381 (PTPN22 dephosphorylates ZAP70)
- Reactome:R-HSA-389758 (Dephosphorylation of CD3-zeta by PD-1 bound phosphatases)
- Reactome:R-HSA-997309 (Dephosphorylation of STAT1 by SHP2)
- Reactome:R-HSA-8849435 (PTPN1 dephosphorylates PTK6)
- Reactome:R-HSA-6807008 (PTPRJ dephosphorylates MET)
- MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN
- Reactome:R-HSA-1549564 (PPTN11 dephosphorylates SPRY2)
- Reactome:R-HSA-203797 (ERKs are inactivated by dual-specific phosphatases (DUSPs))
- Reactome:R-HSA-8852200 (Inactivation of LCK by PTPN22)
- Reactome:R-HSA-74748 (De-phosphorylation of p-Y427-SHC1)
- Reactome:R-HSA-8864036 (PTPN12 dephosphorylates PDGFRB at Y1021)
- Reactome:R-HSA-877308 (Dephosphorylation of JAKs by PTPs)
- Reactome:R-HSA-6807027 (PTPN1 and PTPN2 dephosphorylate MET)
- Reactome:R-HSA-74733 (Insulin receptor de-phosphorylation)
PTPase activity
phosphotyrosine histone phosphatase activity
protein phosphotyrosine phosphatase activity
tyrosylprotein phosphatase activity
[phosphotyrosine]protein phosphatase activity
PTP-phosphatase activity
phosphotyrosine phosphatase activity
phosphotyrosylprotein phosphatase activity
phosphotyrosine protein phosphatase activity
PPT-phosphatase activity
protein-tyrosine-phosphate phosphohydrolase activity
tyrosine O-phosphate phosphatase activity
protein-tyrosine-phosphatase activity
phosphoprotein phosphatase (phosphotyrosine) activity