guanyl-nucleotide exchange factor activity
Go to external page http://purl.obolibrary.org/obo/GO_0005085
Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [ http://www.ncbi.nlm.nih.gov/pubmed/23303910 GOC:mah http://www.ncbi.nlm.nih.gov/pubmed/27218782 GOC:kd ]
Synonyms: RhoGEF GDS Rho guanine nucleotide exchange factor GEF GDP-dissociation stimulator activity guanyl-nucleotide release factor activity guanyl-nucleotide releasing factor
This is just here as a test because I lose it
Term information
database
cross reference
- Reactome:R-HSA-9670436 (p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS)
- Reactome:R-HSA-114544 (p115-RhoGEF activation of RHOA)
- Reactome:R-HSA-428917 (G13 activation by TP receptor)
- Reactome:R-HSA-8851899 (RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET)
- Reactome:R-HSA-9018825 (RHOT2 GEFs activate RHOT2)
- Reactome:R-HSA-9013435 (RHOD auto-activates)
- Reactome:R-HSA-379044 (Liganded Gs-activating GPCR acts as a GEF for Gs)
- Reactome:R-HSA-428535 (Activation of RAC1 by SOS)
- Reactome:R-HSA-3928612 (KALRN exchanges GTP for GDP on RAC1, activating it)
- Reactome:R-HSA-5637806 (SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII))
- Reactome:R-HSA-194518 (RhoA is activated by nucleotide exchange and inhibits axonal growth)
- Reactome:R-HSA-9026891 (NTRK2 activates RAS signaling through SHC1)
- Reactome:R-HSA-9619803 (p-S516-ARHGEF7 activates RAC1)
- Reactome:R-HSA-939265 (Activation of Rap1 by membrane-associated GEFs)
- Reactome:R-HSA-9665404 (RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1)
- Reactome:R-HSA-6811418 (ARFGAPs stimulate ARF GTPase activity at the Golgi membrane)
- Reactome:R-HSA-418579 (Gq activation by P2Y purinoceptor 1)
- Reactome:R-HSA-2424477 (SOS mediated nucleotide exchange of RAS (SHC))
- Reactome:R-HSA-9660824 (ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs)
- Reactome:R-HSA-9032798 (DOCK3 activates RAC1)
- Reactome:R-HSA-9013159 (CDC42 GEFs activate CDC42)
- Reactome:R-HSA-8877612 (DENND1s exchange GTP for GDP on RAB35)
- Reactome:R-HSA-1168636 (p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP)
- Reactome:R-HSA-8876837 (RAB21 GEFs exchange GTP for GDP on RAB21)
- Reactome:R-HSA-8877760 (HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38)
- Reactome:R-HSA-8876616 (DENND6A,B exchange GTP for GDP on RAB14)
- Reactome:R-HSA-442732 (NMDA-activated RASGRF1 activates RAS)
- Reactome:R-HSA-399938 (Activation of Rac1 by FARP2)
- Reactome:R-HSA-2029467 (Activation of RAC1 by CRKII:DOCK180:ELMO)
- Reactome:R-HSA-8875320 (RAB5 GEFs exchange GTP for GDP on RAB5)
- Reactome:R-HSA-8876454 (DENND3 exchanges GTP for GDP on RAB12)
- Reactome:R-HSA-1250463 (RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers)
- Reactome:R-HSA-3928651 (NGEF exchanges GTP for GDP on RHOA)
- Reactome:R-HSA-9018804 (RAC3 GEFs activate RAC3)
- Reactome:R-HSA-5655347 (Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-418856 (Activation of Rac1)
- Reactome:R-HSA-1250498 (RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers)
- Reactome:R-HSA-416530 (FFAR1:FFAR1 ligands activate Gq)
- Reactome:R-HSA-5617816 (RAB3IP stimulates nucleotide exchange on RAB8A)
- Reactome:R-HSA-9639286 (RRAGC,D exchanges GTP for GDP)
- Reactome:R-HSA-9018817 (RHOT1 GEFs activate RHOT1)
- Reactome:R-HSA-389348 (Activation of Rac1 by pVav1)
- Reactome:R-HSA-9672163 (SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers)
- Reactome:R-HSA-9703441 (SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants)
- Reactome:R-HSA-2485180 (MII catalyses GDP/GTP exchange on Gt)
- Reactome:R-HSA-8851827 (RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1)
- Reactome:R-HSA-5654426 (Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-5623521 (RAB3IP stimulates nucleotide exchange on RAB8A)
- Reactome:R-HSA-350769 (trans-Golgi Network Coat Activation)
- Reactome:R-HSA-8877998 (RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18)
- Reactome:R-HSA-210977 (Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos))
- Reactome:R-HSA-9018768 (RHOU auto-activates)
- Reactome:R-HSA-442273 (VAV1 is a GEF for Rho/Rac family GTPases)
- Reactome:R-HSA-8982637 (Opsins binds G alpha-t)
- Reactome:R-HSA-749453 (Liganded Gz-activating GPCR acts as a GEF for Gz)
- Reactome:R-HSA-9033292 (NTRK2 and CDK5 promote activation of RAC1 by TIAM1)
- Reactome:R-HSA-9751201 (p-VAV1,2,3 exchange 6TGTP for GDP on RAC1)
- Reactome:R-HSA-5686318 (GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS)
- Reactome:R-HSA-1225951 (SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants))
- Reactome:R-HSA-400092 (Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins)
- Reactome:R-HSA-9665700 (RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants)
- Reactome:R-HSA-9014296 (RAC2 GEFs activate RAC2)
- Reactome:R-HSA-9013143 (RAC1 GEFs activate RAC1)
- Reactome:R-HSA-9666430 (p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP)
- Reactome:R-HSA-9032067 (NTRK2 activates RAS signaling through FRS2)
- Reactome:R-HSA-187746 (RIT/RIN are activated)
- Reactome:R-HSA-9029158 (EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS)
- Reactome:R-HSA-9018747 (RHOQ GEFs activate RHOQ)
- Reactome:R-HSA-5654663 (Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-419166 (GEFs activate RhoA,B,C)
- Reactome:R-HSA-156913 (Regeneration of eEF1A:GTP by eEF1B activity)
- Reactome:R-HSA-5218839 (DOCK180:ELMO exchanges GTP for GDP, activating RAC1)
- Reactome:R-HSA-9664991 (RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants)
- Reactome:R-HSA-3928642 (TIAM1 exchanges GTP for GDP on RAC1, activating it)
- Reactome:R-HSA-8876193 (RIC1-RGP1 exchanges GTP for GDP on RAB6)
- Reactome:R-HSA-9666428 (DOCK180 exchanges GTP for GDP on RAC1:GDP)
- Reactome:R-HSA-9013023 (RHOB GEFs activate RHOB)
- Reactome:R-HSA-3965444 (WNT:FZD complex promotes G-protein nucleotide exchange)
- Reactome:R-HSA-399995 (Muscarinic Acetylcholine Receptor M3 activates Gq)
- Reactome:R-HSA-5218850 (VAV exchanges GTP for GDP on RAC1, activating it)
- Reactome:R-HSA-3928628 (VAV exchanges GTP for GDP on RAC1, activating it)
- Reactome:R-HSA-2424476 (Activation of RAC1 by VAV2/3)
- Reactome:R-HSA-8851877 (RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET)
- Reactome:R-HSA-5686071 (GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS)
- Reactome:R-HSA-109817 (GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS)
- Reactome:R-HSA-380073 (Liganded Gi-activating GPCR acts as a GEF for Gi)
- Reactome:R-HSA-354173 (Activation of Rap1 by cytosolic GEFs)
- Reactome:R-HSA-9607304 (SOS1-mediated nucleotide exchange of RAS downstream of FLT3)
- Reactome:R-HSA-392870 (Gs activation by prostacyclin receptor)
- Reactome:R-HSA-186834 (SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS))
- Reactome:R-HSA-1433471 (Activation of RAS by p-KIT bound SOS1)
- Reactome:R-HSA-5654402 (Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-5623508 (GBF1 stimulates nucleotide exchange on ARF4)
- Reactome:R-HSA-5655241 (Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-442291 (VAV2 is a GEF for Rho/Rac family kinases)
- Reactome:R-HSA-9665009 (RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR)
- Reactome:R-HSA-5655277 (Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-5655326 (Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-8875591 (DOCK7 activates RAC1)
- Reactome:R-HSA-8964604 (CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated)
- Reactome:R-HSA-9665408 (RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2)
- Reactome:R-HSA-5637808 (SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII))
- Reactome:R-HSA-5654618 (Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-751029 (Liganded G12/13-activating GPCR acts as a GEF for G12/13)
- Reactome:R-HSA-3928632 (ITSN1 exchanges GTP for GDP on CDC42, activating it)
- Reactome:R-HSA-2029451 (Activation of RAC1 by VAV)
- Reactome:R-HSA-8876190 (RAB8 GEFs exchange GTP for GDP on RAB8)
- Reactome:R-HSA-9665707 (RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR)
- Reactome:R-HSA-8848618 (Activation of RAC1 by the PXN:CRK complex)
- Reactome:R-HSA-6811414 (GBF1 stimulates nucleotide exchange on ARF)
- Reactome:R-HSA-8876191 (RAB9 GEFs exchange GTP for GDP on RAB9)
- Reactome:R-HSA-9695853 (FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS)
- Reactome:R-HSA-8875568 (RAPGEF1 activates RAP1)
- Reactome:R-HSA-5694409 (Nucleotide exchange on RAB1)
- Reactome:R-HSA-8875318 (RAB3 GEFs exchange GTP for GDP on RAB3A)
- Reactome:R-HSA-2730840 (Activation of RAC1 by VAV)
- Reactome:R-HSA-5672965 (RAS GEFs promote RAS nucleotide exchange)
- Reactome:R-HSA-9680385 (CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS)
- Reactome:R-HSA-5654413 (Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-8850041 (RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18)
- Reactome:R-HSA-1225957 (SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants))
- Reactome:R-HSA-379048 (Liganded Gq/11-activating GPCRs act as GEFs for Gq/11)
- Reactome:R-HSA-9014433 (RHOG GEFs activate RHOG)
- Reactome:R-HSA-418850 (Activation of Cdc42)
- Reactome:R-HSA-9640167 (RRAGA,B exchanges GDP for GTP)
- Reactome:R-HSA-8877475 (TRAPPC complexes exchange GTP for GDP on RAB1)
- Reactome:R-HSA-1306972 (RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers)
- Reactome:R-HSA-6811429 (RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange)
- Reactome:R-HSA-8877308 (MADD exchanges GTP for GDP on RAB27)
- Reactome:R-HSA-109807 (GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS)
- Reactome:R-HSA-389350 (Activation of Cdc42 by pVav1)
- Reactome:R-HSA-8877311 (RAB31 GEFs exchange GTP for GDP on RAB31)
- Reactome:R-HSA-1433415 (Activation of RAC1)
- Reactome:R-HSA-6807868 (GBF1 stimulates ARF nucleotide exchange)
- Reactome:R-HSA-203977 (SAR1 Activation And Membrane Binding)
- Reactome:R-HSA-205039 (p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor)
- Reactome:R-HSA-9013109 (RHOC GEFs activate RHOC)
- Reactome:R-HSA-3928633 (bPIX exchanges GTP for GDP on RAC, activating it)
- Reactome:R-HSA-1250383 (RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4)
- Reactome:R-HSA-8877813 (DENND5A,B exchange GTP for GDP on RAB39)
- Reactome:R-HSA-4093336 (p-TIAM1 exchanges GTP for GDP on RAC1, activating it)
- Reactome:R-HSA-5218829 (VEGF induces CDC42 activation by unknown mechanism)
- Reactome:R-HSA-170979 ((Frs2)C3G stimulates nucleotide exchange on Rap1)
- Reactome:R-HSA-8876615 (RAB13 GEFs exchange GTP for GDP on RAB13)
- Reactome:R-HSA-2179407 (SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated))
- Reactome:R-HSA-8982640 (G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t))
- Reactome:R-HSA-9017491 (RHOJ GEFs activate RHOJ)
- Reactome:R-HSA-9693111 (RHOF auto-activates)
- Reactome:R-HSA-177938 (SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1))
- Reactome:R-HSA-3928592 (p190RhoGEF exchanges GTP for GDP on RHOA, activating it)
- Reactome:R-HSA-5654647 (Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-171026 (Guanine nucleotide exchange on RAL)
- Reactome:R-HSA-392195 (Gi activation by P2Y purinoceptor 12)
- Reactome:R-HSA-177945 (SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1))
- Reactome:R-HSA-9634418 (RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1)
- Reactome:R-HSA-392054 (NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras)
- Reactome:R-HSA-9036301 (ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s)
- Reactome:R-HSA-8876188 (DENND4s exchange GTP for GDP on RAB10)
- Reactome:R-HSA-9672170 (SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors)
- Reactome:R-HSA-420883 (Opsins act as GEFs for G alpha-t)
- Reactome:R-HSA-8980691 (RHOA GEFs activate RHOA)
- Reactome:R-HSA-180687 (Conversion of Ran-GDP to Ran-GTP)
- Reactome:R-HSA-9624845 (RCC1 stimulates GDP to GTP exchange on RAN)
- Reactome:R-HSA-416588 (Activation of Rho by LARG and PDZ-RhoGEF)
- Reactome:R-HSA-2029445 (An unknown GEF exchanges GTP for GDP on CDC42:GDP)
- Reactome:R-HSA-5654392 (Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-442314 (VAV3 is a GEF for Rho/Rac family kinases)
- Reactome:R-HSA-825631 (Glucagon:GCGR mediates GTP-GDP exchange)
- Reactome:R-HSA-169904 (C3G stimulates nucleotide exchange on Rap1)
- Reactome:R-HSA-445064 (Activation of Rac1 by VAV2)
- Reactome:R-HSA-8877451 (MON1:CCZ1 exchanges GTP for GDP on RAB7)
- Reactome:R-HSA-5654600 (Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange)
- Reactome:R-HSA-428750 (Gq activation by TP receptor)
Subsets
goslim_chembl, goslim_drosophila, goslim_yeast
has alternative id
GO:0005090
GO:0016219
GO:0019839
GO:0005086
GO:0005088
GO:0005087
GO:0008433
GO:0005089
GO:0008321
GO:0017132
GO:0016220
GO:0017034
GO:0017112
GO:0030676
has narrow synonym
Ral guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
GNRP
Rac guanyl-nucleotide exchange factor activity
Rap guanyl-nucleotide exchange factor activity
Sar guanyl-nucleotide exchange factor activity
Rab guanyl-nucleotide exchange factor activity
Ran guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity
cAMP-dependent guanyl-nucleotide exchange factor activity
ARF guanyl-nucleotide exchange factor activity
term tracker item
https://github.com/geneontology/go-ontology/issues/18750
https://github.com/geneontology/go-ontology/issues/27684
https://github.com/geneontology/go-ontology/issues/18749
Term relations
Subclass of:
- GTPase regulator activity
- negatively regulates some GDP binding
- positively regulates some GTP binding