The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. [ GOC:jl http://www.ncbi.nlm.nih.gov/pubmed/11788607 ]
Synonyms: heme anabolism heme biosynthesis heme formation heme synthesis haem biosynthesis haem biosynthetic process