The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [ https://www.worldcat.org/search?q=bn%3A0198506732 ]
Synonyms: nucleotide-sugar synthesis nucleotide-sugar formation nucleotide-sugar anabolism nucleotide-sugar biosynthesis