Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. [ http://www.ncbi.nlm.nih.gov/pubmed/19763486 http://www.ncbi.nlm.nih.gov/pubmed/16564093 https://www.rhea-db.org/rhea/32727 ]
Synonyms: very-long-chain beta-ketoacyl-CoA synthase very-long-chain 3-ketoacyl-CoA synthase very-long-chain 3-oxoacyl-CoA synthase elongation of very long chain fatty acids activity ELOVL
Term information
- Reactome:R-HSA-2046094 (Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA)
- Reactome:R-HSA-2046100 (Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA)
- Reactome:R-HSA-548814 (ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA)
- Reactome:R-HSA-2046095 (Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA)
- MetaCyc:RXN-7697
- Reactome:R-HSA-548830 (ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA)
- EC:2.3.1.199
- Reactome:R-HSA-2046083 (Elongation of arachidonyl-CoA to docosatetraenoyl-CoA)
- Reactome:R-HSA-548815 (ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA)
- RHEA:32727
- Reactome:R-HSA-2046088 (Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA)
- Reactome:R-HSA-2046090 (Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA)
- Reactome:R-HSA-548800 (ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA)
https://github.com/geneontology/go-ontology/issues/24752
https://github.com/geneontology/go-ontology/issues/25805