Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [ GOC:mah https://www.rhea-db.org/rhea/48348 ]
Term information
- Reactome:R-HSA-8870289 (PUS3 transforms uridine-39 to pseudouridine-39 in tRNA)
- Reactome:R-HSA-6787566 (PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser))
- Reactome:R-HSA-6782381 (PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs)
- RHEA:48348
- Reactome:R-HSA-6786583 (PUS7 transforms uridine to pseudouridine in tRNAs)
- Reactome:R-HSA-6790905 (Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA)
Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate.