The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. [ http://www.ncbi.nlm.nih.gov/pubmed/22785621 http://www.ncbi.nlm.nih.gov/pubmed/11113136 http://www.ncbi.nlm.nih.gov/pubmed/11239395 http://www.ncbi.nlm.nih.gov/pubmed/30601114 GOC:sart ]