NAD-dependent protein lysine deacetylase activity
Go to external page http://purl.obolibrary.org/obo/GO_0034979
Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide. [ GOC:BHF https://www.rhea-db.org/rhea/43636 GOC:mah ]
Synonyms: NAD(+)-dependent protein deacetylase
Term information
- Reactome:R-HSA-9620532 (SIRT1,SIRT3 deacetylate FOXO3)
- Reactome:R-HSA-5688294 (SIRT5 deacetylates Cytochrome C)
- Reactome:R-HSA-5688289 (SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2)
- Reactome:R-HSA-3371467 (SIRT1 deacetylates HSF1)
- Reactome:R-HSA-9667952 (ANKLE2 is deacetylated by SIRT2)
- EC:2.3.1.286
- Reactome:R-HSA-9854463 (SIRT3 deacetylates AcK-IDH2 dimer)
- RHEA:43636
- Reactome:R-HSA-5685953 (SIRT6 deacetylates RBBP8)
- Reactome:R-HSA-5211239 (SIRT1 deacetylates TAF1B in SL1 complex)
protein lysine deacetylase
NAD-dependent protein deacetylase activity
protein lysine deacylase
protein acetyllysine N-acetyltransferase
NAD(+)-dependent protein deacylase
https://github.com/geneontology/go-ontology/issues/27528
https://github.com/geneontology/go-ontology/issues/22295