A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane. [ http://www.ncbi.nlm.nih.gov/pubmed/22179047 GOC:sp http://www.ncbi.nlm.nih.gov/pubmed/26982032 GOC:cilia http://www.ncbi.nlm.nih.gov/pubmed/21565611 http://www.ncbi.nlm.nih.gov/pubmed/26595381 http://www.ncbi.nlm.nih.gov/pubmed/25869670 http://www.ncbi.nlm.nih.gov/pubmed/21725307 http://www.ncbi.nlm.nih.gov/pubmed/21422230 ]
Synonyms: MKS module
Term information
Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.