Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles. [ http://www.ncbi.nlm.nih.gov/pubmed/15239958 http://www.ncbi.nlm.nih.gov/pubmed/27903609 ]
Term information
- Reactome:R-HSA-9759202 (LRP2-mediated TCN2:RCbl uptake and delivery to lysosome)
- Reactome:R-HSA-3000122 (CD320 binds extracellular TCN2:RCbl)
- Reactome:R-HSA-203716 (eNOS:Caveolin-1 complex binds to Nostrin)
- Reactome:R-HSA-350168 (LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D)
- Reactome:R-HSA-9759209 (LRP2 binds extracellular TCN2:RCbl)
- Reactome:R-HSA-3000103 (CUBN:AMN binds CBLIF:RCbl)
- Reactome:R-HSA-3000112 (CD320-mediated TCN2:RCbl uptake and delivery to lysosome)
- Reactome:R-HSA-3000137 (CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome)
goslim_generic, goslim_drosophila
Notes: (1) For receptors binding a molecule but coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857'.
endocytic receptor activity
receptor activity involved in receptor-mediated endocytosis