The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. [ GOC:jc http://en.wikipedia.org/wiki/Neurotrophin http://www.ncbi.nlm.nih.gov/pubmed/17466268 GOC:signaling GOC:bf ]
Synonyms: neurotrophin receptor signaling pathway
Term information
There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.