A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. [ GOC:jl http://www.ncbi.nlm.nih.gov/pubmed/10631934 ]
Synonyms: peptide-loading complex
Term information
goslim_pir
Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
Term relations
- membrane protein complex
- endoplasmic reticulum protein-containing complex
- part of some endoplasmic reticulum membrane