The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls. [ http://www.ncbi.nlm.nih.gov/pubmed/22580823 ]
Synonyms: 3' processing reaction 3'-processing activity
Term information
This reaction may serve to remove heterogeneous extra bases from the viral DNA end, and to stabilize the integrase-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification.