The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity. [ http://www.ncbi.nlm.nih.gov/pubmed/23010169 http://www.ncbi.nlm.nih.gov/pubmed/24709372 GOC:dph GOC:pad GOC:PARL ]