A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven. [ http://www.ncbi.nlm.nih.gov/pubmed/9670020 GOC:mah GOC:bhm ]
Synonyms: SMAD complex