A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). [ http://www.ncbi.nlm.nih.gov/pubmed/15989961 http://www.ncbi.nlm.nih.gov/pubmed/19748353 GOC:vw http://www.ncbi.nlm.nih.gov/pubmed/22980980 http://www.ncbi.nlm.nih.gov/pubmed/16732272 http://www.ncbi.nlm.nih.gov/pubmed/20381137 http://www.ncbi.nlm.nih.gov/pubmed/19177150 http://www.ncbi.nlm.nih.gov/pubmed/29199950 ]