The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system. [ http://www.ncbi.nlm.nih.gov/pubmed/11146663 http://www.ncbi.nlm.nih.gov/pubmed/8524399 http://www.ncbi.nlm.nih.gov/pubmed/11084334 ]