Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. [ GOC:BHF GOC:rl GOC:go_curators http://www.ncbi.nlm.nih.gov/pubmed/10615049 GOC:aa http://en.wikipedia.org/wiki/Acid http://www.ncbi.nlm.nih.gov/pubmed/19170886 ]