A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the correct folding of multipass membrane proteins in the ER membrane. In human, the substrate-binding Asterix (PAT10, WDR83OS) forms an obligate heterodimer with CCDC47. [ http://www.ncbi.nlm.nih.gov/pubmed/33082068 http://www.ncbi.nlm.nih.gov/pubmed/32814900 http://www.ncbi.nlm.nih.gov/pubmed/33960686 ]
Term information
PAT complex functions by shielding exposed hydrophilicity of transmembrane domains (TMDs) to prevent premature degradation and promote proper folding and bundling of TMDs.