The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels. [ http://www.ncbi.nlm.nih.gov/pubmed/17553987 http://www.ncbi.nlm.nih.gov/pubmed/24653208 GOC:kmv ]