A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins. [ GOC:bhm http://www.ncbi.nlm.nih.gov/pubmed/24311597 ]

This is just here as a test because I lose it

Term information

comment

An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay).

creation date

2015-06-26T13:49:47Z

has obo namespace

cellular_component

id

GO:1990788

Term relations