An autophagy-related protein that functions in AUTOPHAGOSOME biogenesis. It is conjugated to the ATG12 PROTEIN via a process that is similar to UBIQUITINATION and involves the ATG7 PROTEIN and ATG10 enzyme. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme and is required for the localization of ATG8 PROTEINS to AUTOPHAGOSOME vesicle membranes and modification of membrane lipids.

Synonyms: Autophagy Protein 5, 0, Autophagy Related Protein 5, Autophagy Related 5 Protein, Autophagy Protein-5, ATG 5 Protein, Autophagy-Related Protein 5, ATG5 Protein, Autophagy-Related 5 Protein, ATG-5 Protein, Apoptosis Specific Protein, Apoptosis-Specific Protein