An autophagy related protein that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.

Synonyms: Ubiquitin-Like Modifier-Activating Enzyme ATG7, ATG12-Activating Enzyme E1 ATG7, Autophagy-Related Protein 7, Ubiquitin-Activating Enzyme E1-like Protein, Ubiquitin Like Modifier Activating Enzyme ATG7, Ubiquitin Activating Enzyme E1 like Protein, Autophagy Related Protein 7, ATG7 Protein, EC 6.2.1.45, ATG12 Activating Enzyme E1 ATG7