A dioxygenase and alkylation repair homolog that catalyzes the methylation of 5-carboxymethyl URIDINE to 5-methylcarboxymethyl uridine at the wobble position of the ANTICODON loop in TRANSFER RNA (tRNA) via its methyltransferase domain. It has a preference for tRNA (ARGININE) and tRNA (GLUTAMATE), and does not bind tRNA (LYSINE).

Synonyms: tRNA (Carboxymethyluridine(34)-5-O)-Methyltransferase ABH8, Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH8, Probable Alpha Ketoglutarate Dependent Dioxygenase ABH8, Alkylated DNA Repair Protein Alkb Homolog 8, S Adenosyl L Methionine Dependent tRNA Methyltransferase ABH8, S-Adenosyl-L-Methionine-Dependent tRNA Methyltransferase ABH8, EC 1.14.11.-, AlkB Homolog 8, tRNA Methyltransferase