A disintegrin and metalloproteinase domain-containing protein. It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN.

Synonyms: EC 3.4.24.81, CD156w Antigen, Antigen, CD156w, Disintegrin and Metalloproteinase Domain-Containing Protein 10, Disintegrin and Metalloproteinase Domain Containing Protein 10, ADAM10 Protein, CD156c Antigen, ADAM 10 Protein, Antigen, CD156c, ADAM-10 Protein