P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.

Synonyms: ATPase 2, Copper-Transporting, Wilson Disease Cu-Binding P Type ATPase, Copper-Transporting Adenosine Triphosphatases, Copper Transporting ATPase, ATP7A Protein, Copper Transporting ATPases, ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease), Pineal Night-Specific ATPase, ATP7B Cu Binding P Type ATPase, Menkes Disease-Associated Protein, Triphosphatases, Copper-Transporting Adenosine, Wilson Disease Protein, Copper Pump 1, Adenosine Triphosphatases, Copper-Transporting, Wilson Disease Cu Binding P Type ATPase, ATPase, Pineal Night-Specific, ATPase Copper Transporting alpha, Night-Specific ATPase, Pineal, ATPases, Copper-Transporting, Copper Transporting ATPase 1, EC 7.2.2.8, ATPase, Copper-Transporting, EC 3.6.3.54, Copper-Transporting ATPase, ATPases, Cu-Transporting, PINA Enzyme, Cu(+)-Transporting ATPases, Copper-Transporting ATPase 1, Menkes Disease Associated Protein, Pineal Night Specific ATPase, Copper-Transporting ATPase 2, Cu Transporting ATPases, Copper Transporting ATPase 2, 0, ATPase 1, Copper-Transporting, ATP7B Cu-Binding P Type ATPase, Cu-Transporting ATPases, Copper Transporting Adenosine Triphosphatases, Copper-Transporting ATPases