A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

Synonyms: 0, GLI Kruppel Family Member 3 Protein, Glioma-Associated Oncogene Family Zinc Finger 3 Protein, Zinc Finger Protein Gli3, Glioma Associated Oncogene Family Zinc Finger 3 Protein, GLI-Kruppel Family Member 3 Protein