A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.

Synonyms: 0, Aldo-Keto Reductases, Reductases, Aldo-Keto, Aldo-Keto Reductase Family, Aldo Keto Reductase, EC 1.1.1.-, Aldo Keto Reductases, Aldo-Keto Reductase, Aldo Keto Reductase Family, Reductase, Aldo-Keto, Aldo Keto Reductase Superfamily, Aldo-Keto Reductase Superfamily