A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding.

Synonyms: 0, Anoctamin, Protein Family, TMEM16, TMEM16 Protein Family, Anoctamins, TMEM16 Proteins