A synthetic or processed 14-amino acid peptide that is used to measure RENIN activities.

An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.

Synonyms: 0, Renin-Substrate, Angiotensinogen (protein renin substrate), Hypertensinogen, Serpin A8, Renin Substrate, Tetradecapeptide, Renin Substrate, Angiotensinogen, Renin Substrate Tetradecapeptide, SERPINA8, 11002-13-4, Proangiotensin