An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.

Synonyms: Leukotriene A4 Synthetase, 5 Lipoxygenase, Synthase, Leukotriene A4, Arachidonate:oxygen 5-oxidoreductase, Synthase, Leukotriene A, LTA4 Synthase, Arachidonate 5 Lipoxygenase, Synthase, LTA4, Leukotriene A4 Synthase, Leukotriene A Synthase, 5-Lipoxygenase, Arachidonate, Arachidonic Acid 5-Lipoxygenase, 5-Lipoxygenase, Arachidonate 5-Lipoxygenase, Arachidonic Acid 5 Lipoxygenase, EC 1.13.11.34, 5-Lipoxygenase, Arachidonic Acid, Synthetase, Leukotriene A4