A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.

Synonyms: EPB3 Protein, Protein Band 3, Solute Carrier Family 4 Member 1, Protein, EPB3, SLC4A1 Protein, Anion Exchange Protein 1, Erythrocyte, Chloride-Bicarbonate Exchanger, AE1, Anion Exchanger 1, Erythrocyte Membrane Anion Transport Protein, Anion Exchanger, Erythrocyte, Solute Carrier Family 4, Anion Exchanger, Member 1, AE1 Chloride-Bicarbonate Exchanger, Erythrocyte Anion Transport Protein, CD233 Antigens, Exchanger 1, Anion, Antigens, CD233, Erythrocyte Anion Exchanger, Anion Transport Protein, Erythrocyte, Erythrocyte Membrane Protein Band 3, Diego Blood Group, Band 3 Protein, AE1 Gene Product, Band III Protein, AE1 Cl HCO3 Exchanger, AE1 Cl- HCO3- Exchanger, AE1 Anion Exchanger, 0, Capnophorin, CD233 Antigen, Band 3 Anion Transport Protein, Antigen, CD233, Erythrocyte Membrane Band 3 Protein, AE1 Chloride Bicarbonate Exchanger