A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)

Synonyms: Hypotension Syndrome, Dysautonomia-Orthostatic, Syndromes, Dysautonomia-Orthostatic Hypotension, Hypotension Syndromes, Dysautonomia-Orthostatic, Progressive Autonomic Failures, Autonomic Failures, Progressive, Hypotension, Dysautonomic Orthostatic, Dysautonomia Orthostatic Hypotension Syndrome, Syndrome, Dysautonomia-Orthostatic Hypotension, Failures, Progressive Autonomic, Idiopathic Orthostatic Hypotension, Shy Drager Type, Progressive Autonomic Failure, Dysautonomia-Orthostatic Hypotension Syndrome, Dysautonomic Orthostatic Hypotension, Failure, Progressive Autonomic, Hypotensions, Dysautonomic Orthostatic, Dysautonomic Orthostatic Hypotensions, Syndrome, Shy-Drager, Dysautonomia-Orthostatic Hypotension Syndromes, Orthostatic Hypotension, Dysautonomic, Idiopathic Orthostatic Hypotension, Shy-Drager Type, Shy-Drager Syndrome, Orthostatic Hypotensions, Dysautonomic, Shy Drager Syndrome, Autonomic Failure, Progressive, Syndrome, Dysautonomia Orthostatic Hypotension