An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.

Synonyms: Organizing Pneumonias, Cryptogenic, BOOP, Bronchiolitis Obliterans Organizing Pneumonia, Pneumonia, Cryptogenic Organizing, Cryptogenic Organizing Pneumonia, Cryptogenic Organizing Pneumonias, Pneumonias, Cryptogenic Organizing, Organizing Pneumonia, Cryptogenic