Techniques where DNA is delivered directly into organelles at high speed using projectiles coated with nucleic acid, shot from a helium-powered gun (gene gun). One of these techniques involves immunization by DNA VACCINES, which delivers DNA-coated gold beads to the epidermis.

Synonyms: Particle Mediated Epidermal Delivery of DNA, Gene-Gun Technique, Gene Gun Technique, Biolistics, Gene-Gun Techniques, Particle-Mediated Epidermal Delivery of DNA, Biolistic, Gene Gun DNA Immunization