A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
Synonyms: 0, Mitochondrial Apoptosis-Inducing Factor, Mitochondrial Apoptosis Inducing Factor, Apoptosis Inducing Factor, Apoptosis-Inducing Factor, Mitochondrial, AIF Apoptosis Regulatory Protein, Apoptosis-Inducing Factor
Instance information
2006(1999) ,INHIBITOR OF APOPTOSIS PROTEINS is also available ,2006; APOPTOSIS INDUCING FACTOR was indexed under FLAVOPROTEINS & MEMBRANE PROTEINS 1999-2005
D051033