Rare autosomal recessive disease characterized by multiple organ dysfunction. The key clinical features include retinal degeneration (NYSTAGMUS, PATHOLOGIC; RETINITIS PIGMENTOSA; and eventual blindness), childhood obesity, sensorineural hearing loss, and normal mental development. Endocrinologic complications include TYPE 2 DIABETES MELLITUS; HYPERINSULINEMIA; ACANTHOSIS NIGRICANS; HYPOTHYROIDISM; and progressive renal and hepatic failures. The disease is caused by mutations in the ALMS1 gene.

Synonyms: Alstrom's Syndrome, Syndrome, Alstrom, Syndrome, Alström, Syndrome, Alstrom's, Alstrom-Hallgren Syndrome, Alstroms Syndrome, Alström Syndrome, Syndrome, Alstrom-Hallgren, Alstrom Hallgren Syndrome, Alstrom Syndrome