Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.

Synonyms: 0, Catechol O Methyltransferase Inhibitors, Catechol O-Methyltransferase Inhibitors, O-Methyltransferase Inhibitors, Catechol