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Aotus trivirgatus
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D001029 |
[A species in the family AOTIDAE, inhabiting the forested regions of Central and South America (from Panama to the Amazon). Vocalizations occur primarily at night when they are active, thus they are also known as Northern night monkeys.
] |
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Apamin
|
D001030 |
[A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfide bridges and causes hyperexcitability resulting in convulsions and respiratory paralysis.
] |
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Apansporoblastina
|
D016817 |
[A suborder of FUNGI in the phylum MICROSPORIDIA, commonly lacking a pansporoblastic membrane. The sporoblast is usually dinucleate.
] |
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Apartheid
|
D000072698 |
[A former political system in SOUTH AFRICA which enforced segregation in all forms, including physical, political, legal and economic discrimination, against all non-white, non-European racial groups.
] |
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Apathy
|
D057565 |
[Lack of emotion or emotional expression; a disorder of motivation that persists over time.
] |
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Apatites
|
D001031 |
[A group of phosphate minerals that includes ten mineral species and has the general formula X5(YO4)3Z, where X is usually calcium or lead, Y is phosphorus or arsenic, and Z is chlorine, fluorine, or OH-. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
] |
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Apazone
|
D001032 |
[An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.
] |
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Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
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D064189 |
[The largest subunit of the anaphase-promoting complex. It acts primarily as a scaffold for the proper organization and arrangement of subunits. The C-terminal region of Apc1 contains a series of tandem amino acid repeats that are also seen in the 26S proteasome regulatory particle, and may assist with forming and stabilizing protein-protein interactions.
] |
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Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
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D064197 |
[Apc10 is necessary for coactivator-dependent substrate recognition by the anaphase-promoting complex-cyclosome. It binds the Apc2 subunit, which is a part of the catalytic core, and interacts with coactivators Cdh1 or Cdc20 to recruit substrates to the complex.
] |
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Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
|
D064198 |
[Together with the Apc2 subunit, forms the catalytic core of the E3 ubiquitin ligase, anaphase-promoting complex-cyclosome. It has a RING H2 domain which interacts with the cullin domain of Apc2. Apc11 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.
] |
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Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
|
D064190 |
[Together with the Apc11 subunit, forms the catalytic core of the E3 ubiquitin ligase anaphase-promoting complex (APC-C). Its N-terminus has cullin domains which associate with the RING FINGER DOMAINS of Apc11. Apc2 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.
] |
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Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
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D064191 |
[A highly evolutionarily conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc subunits 6, 7, and 8, have been shown to mediate protein-protein interactions, suggesting that Apc3 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to co-activators and APC-C inhibitors.
] |
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Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome
|
D064192 |
[A subunit of the anaphase-promoting complex whose primary function is to provide structural support for the catalytic and substrate-recognition modules of the complex. Apc4, along with Apc5, tethers the tetratricopeptide-coactivator binding subcomplex to the main structural subunit, Apc1.
] |
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Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
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D064193 |
[A subunit of the anaphase-promoting complex whose primary function is to provide structural support for the catalytic and substrate-recognition modules of the complex. Apc5, along with Apc4, tethers the tetratricopeptide-coactivator binding subcomplex to the main structural subunit, Apc1.
] |
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Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
|
D064194 |
[A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34 amino acid tetratricopeptide repeats. These domains, also found in Apc3, Apc7, and Apc8, have been shown to mediate protein-protein interactions, suggesting that Apc6 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
] |
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Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
|
D064195 |
[A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34 amino acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc8, have been shown to mediate protein-protein interactions, suggesting that Apc7 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
] |
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Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
|
D064196 |
[A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc7, have been shown to mediate protein-protein interactions, suggesting that Apc8 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
] |
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Ape Diseases
|
D018420 |
[Diseases of chimpanzees, gorillas, and orangutans.
] |
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Apelin
|
D000073861 |
[A 77 amino acid secreted endogenous ligand for the angiotensin II receptor-like 1 protein (APELIN RECEPTOR) that is proteolytically cleaved into four smaller peptides: Apelin-36, Apelin-31, Apelin-28, and Apelin-13. It inhibits entry of HIV into cells that express both APJ and CD4 ANTIGEN and is highly expressed in breast milk, where it may modulate the neonatal immune response.
] |
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Apelin Receptors
|
D000075244 |
[G-protein coupled receptors for APELIN that function in a broad range of physiologic processes including blood pressure regulation and heart contractility. They also have an essential role in early embryo development for GASTRULATION and heart morphogenesis, and can also function as a CD4 co-receptor for HIV-1.
] |
